Evaluación in vitro de la efectividad del aceite esencial de Chamaemelum nobile y Eucalyptus frente a Candida albicans ATCC
Palabras clave:
Política de la salud, servicio de salud, odontología, (Tesauro UNESCO).
Resumen
La investigación se centró en analizar la eficacia del aceite esencial obtenido de manzanilla (Chamaemelum Nobile) y eucalipto (Eucalyptus) frente a la Candida albicans sensible (ATCC® 90028). Fue laboratorial in vitro de corte longitudinal, con el fin de analizar la eficacia del aceite esencial de manzanilla, eucalipto y una combinación de ambas sustancias frente a Candida albicans sensible (ATCC® 90028), en concentraciones del 50%, 75% y 100%. Se determinó que el aceite esencial de manzanilla presentó un efecto inhibitorio frente a Candida albicans sensible (ATCC® 90028), en concentraciones del 75% y 100%. Adicionalmente, el fluconazol, que actúa como control positivo, presentó una zona de inhibición de 19 mm en los mismos escenarios de concentración. El aceite esencial de manzanilla mostró una mayor eficacia frente a Candida albicans sensible (ATCC® 90028), a concentraciones del 75% y del 100%.
Descargas
La descarga de datos todavía no está disponible.
Citas
Alizadeh, B., Tabatabaei, F., Vasiee, A., y Mortazavi, S. (2018). Oliveria decumbens essential oil: Chemical compositions and antimicrobial activity against the growth of some clinical and standard strains causing infection. Microbial Pathogenesis, 1-17. https://doi.org/10.1016/j.micpath.2017.12.033
Araiza, J., Sánchez, V., Carillo, A., Fernández, D., Tejada, J., y Bonifaz, A. (2023). Mixed oral candidiasis in type 2 diabetic patients: Identification and spectrum of sensitivity. Biomédica, 43, 97-108. https://doi.org/10.7705/BIOMEDICA.6878
Argüelles, J., Sánchez, R., Argüelles, A., y Solano, F. (2024). Natural substances as valuable alternative for improving conventional antifungal chemotherapy: Lights and shadows. Journal of Fungi, 10, 1-19. https://doi.org/10.3390/jof10050334
Atanas, G., Sergey, B., Verana, M., & Claudiu, T. (2021). Natural products in drug discovery: Advances and opportunities. Nature Reviews Drug Discovery, 20(3), 200-216. https://doi.org/10.1038/s41573-020-00114-z
Balázs, V., Horváth, B., Kerekes, E., Ács, K., Kocsis, B., Varga, A., Böszörményi, A., Nagy, D., Krisch, J., Széchenyi, A., & Horváth, G. (2019). Anti-Haemophilus activity of selected essential oils detected by TLC-direct bioautography and biofilm inhibition. Molecules, 1-15. https://doi.org/10.3390/molecules24183301
Barcia, G. (2022). Fungal infections of cutaneous and superficial affectation. Dominio de Las Ciencias, 8(3), 2085-2113. https://doi.org/10.23857/dc.v8i3
Bedoya, M., Lázaro, B., Bizarro, A., Gutti, Y., Poma, K., y Cisnero, B. (2023). Eucaliptol: Una vista de la medicina tradicional en el siglo XXI. Eucalyptol: A View of Traditional Medicine in XXI Century. https://orcid.org/0000-0003-
Bukvicki, D., Kumur, A., Gottardi, D., Tabanelli, G., Montanari, C., Malik, A., & Guerzoni, M. (2014). Eucalyptus essential oil as a natural food preservative: In vivo and in vitro antiyeast potential. BioMed Research International, 2014, 1-9. https://doi.org/10.1155/2014/969143
Burt, S. (2004). Essential oils: Their antibacterial properties and potential applications in foods - A review. International Journal of Food Microbiology, 94(3), 223-253. https://doi.org/10.1016/j.ijfoodmicro.2004.03.022
Cama, D., Villanueva, E., Sakoda, B., y Monzon, L. (2020). Extraction and chemical characterization of essential oil from eucalyptus obtained by microwave and ultrasound. Revista de Investigación Altoandina, 22, 1-11. https://doi.org/10.18271/ria.2020.661
Cuenca, K., Lima, M., Pacheco, E., Vélez, E., y Zarzuelo, A. (2024). Effectiveness of lemon verbena (Cymbopogon citratus) in oral candidiasis: A systematic review. Clinical, Cosmetic and Investigational Dentistry, 16, 295-305. https://doi.org/10.2147/ccide.s478181
Cuenca, K., Pacheco, E., Granda, Y., Vélez, E., y Zarzuelo, A. (2022). Phytotherapy: A solution to decrease antifungal resistance in the dental field. Biomolecules, 12(6), 1-16. https://doi.org/10.3390/biom12060789
Dadar, M., Tiwari, R., Karthik, K., Chakraborty, S., Shahali, Y., & Dhama, K. (2018). Candida albicans - Biology, molecular characterization, pathogenicity, and advances in diagnosis and control – An update. Microbial Pathogenesis, 117, 128-138. https://doi.org/10.1016/j.micpath.2018.02.028
Dagli, N., Dagli, R., Mahmoud, R., & Baroudi, K. (2015). Essential oils, their therapeutic properties, and implication in dentistry: A review. Journal of International Society of Preventive and Community Dentistry, 5(5), 335-340. https://doi.org/10.4103/2231-0762.165933
García, C., Sarrion, M., y Bagán, J. (2014). Current treatment of oral candidiasis: A literature review. Journal of Clinical and Experimental Dentistry, 6(5), 576-582. https://doi.org/10.4317/jced.51798
Gharibpour, F., Shirban, F., Bagherniya, M., Nosouhian, M., Sathyapalan, T., & Sahebkar, A. (2021). The effects of nutraceuticals and herbal medicine on Candida albicans in oral candidiasis: A comprehensive review. https://doi.org/10.1007/978-3-030-64872-5_16
Gómez, A., López, Y., y Aguirre, M. (2022). Microbioma oral: Variabilidad entre regiones y poblaciones. Revista de La Facultad de Medicina, 65(5), 8-19. https://doi.org/10.22201/fm.24484865e.2022.65.5.02
Höferl, M., Wanner, J., Tabanca, N., Ali, A., Gochev, V., Schmidt, E., Kaul, V., Singh, V., & Jirovetz, L. (2020). Biological activity of Matricaria chamomilla essential oils of various chemotypes. Planta Medica International Open, 7(3), 114-121. https://doi.org/10.1055/a-1186-2400
Ivanov, M., Ćirić, A., & Stojković, D. (2022). Emerging antifungal targets and strategies. International Journal of Molecular Sciences, 23(5), 1-26. https://doi.org/10.3390/ijms23052756
Ivanov, M., Kannan, A., Stojković, D., Glamočlija, J., Calhelha, R., Ferreira, I., Sanglard, D., & Soković, M. (2021). Camphor and eucalyptol—Anticandidal spectrum, antivirulence effect, efflux pumps interference and cytotoxicity. International Journal of Molecular Sciences, 22, 1-14. https://doi.org/10.3390/ijms22020483
Jarrin, M., Caicedo, M., Garrido, P., y Cepeda, H. (2022). Terapia fotodinámica antimicrobiana sobre Candida albicans en superficies acrílicas de prótesis dentales: Estudio in vitro. Revista Eugenio Espejo, 16(3), 72-82. https://doi.org/10.37135/ee.04.15.08
Mihyaoui, A., Esteves Da Silva, J., Charfi, S., Castillo, M., Lamarti, A., & Arnao, M. (2022). Chamomile (Matricaria chamomilla L.): A review of ethnomedicinal use, phytochemistry and pharmacological uses. Life, 12(4), 1-41. https://doi.org/10.3390/life12040479
Noshirvani, N., Fasihi, H., Hashemi, M., Fazilati, M., Salavati, H., & Coma, V. (2019). Antioxidant and antimicrobial properties of carbohydrate-based films enriched with cinnamon essential oil by Pickering emulsion method. Food Packaging and Shelf Life, 19, 147-154. https://doi.org/10.1016/j.fpsl.2018.12.007
Palabaş, S., & Koca, C. (2020). Ethnobotanical survey of medicinal plants traded in herbal markets of Kahramanmaraş. Plant Diversity, 42(6), 443-454. https://doi.org/10.1016/j.pld.2020.12.003
Pazmiño, K. (2022). Epidemiología y susceptibilidad antifúngica en América Latina: Revisión bibliográfica narrativa. Trabajo de titulación previo a la obtención de título de Bioquímica Clínica. Pontificia Universidad Católica del Ecuador.
Sharifzadeh, A., & Shokri, H. (2016). Antifungal activity of essential oils from Iranian plants against fluconazole-resistant and fluconazole-susceptible Candida albicans. Original Research Article, 6(2).
Singh, O., Khanam, Z., Misra, N., & Srivastava, M. (2011). Chamomile (Matricaria chamomilla L.): An overview. Pharmacognosy Reviews, 5(9), 82-95. https://doi.org/10.4103/0973-7847.79103
Tamura, M., Watanabe, K., Mikami, Y., Yazawa, K., & Nishimura, K. (2001). Molecular characterization of new clinical isolates of Candida albicans and C. dubliniensis in Japan: Analysis reveals a new genotype of C. albicans with group I intron. Journal of Clinical Microbiology, 39(12), 4309-4315. https://doi.org/10.1128/JCM.39.12.4309-4315.2001
Tang, X., Shao, Y. L., Tang, Y. J., & Zhou, W. W. (2018). Antifungal activity of essential oil compounds (geraniol and citral) and inhibitory mechanisms on grain pathogens (Aspergillus flavus and Aspergillus ochraceus). Molecules, 23(9), 1-18. https://doi.org/10.3390/molecules23092108
Tiwari, A., & Khasbage, S. (2024). Oral thrush: An entity with diagnostic dilemma. Cureus, 2, 1-8. https://doi.org/10.7759/cureus.54916
Visan, A., & Negut, I. (2024). Coatings based on essential oils for combating antibiotic resistance. Antibiotics, 13(7), 1-37. https://doi.org/10.3390/antibiotics13070625
Wall, G., y Lopez, J. (2020). Current antimycotics, new prospects, and future approaches to antifungal therapy. Antibiotics, 9(8), 1-10. https://doi.org/10.3390/antibiotics9080445
Araiza, J., Sánchez, V., Carillo, A., Fernández, D., Tejada, J., y Bonifaz, A. (2023). Mixed oral candidiasis in type 2 diabetic patients: Identification and spectrum of sensitivity. Biomédica, 43, 97-108. https://doi.org/10.7705/BIOMEDICA.6878
Argüelles, J., Sánchez, R., Argüelles, A., y Solano, F. (2024). Natural substances as valuable alternative for improving conventional antifungal chemotherapy: Lights and shadows. Journal of Fungi, 10, 1-19. https://doi.org/10.3390/jof10050334
Atanas, G., Sergey, B., Verana, M., & Claudiu, T. (2021). Natural products in drug discovery: Advances and opportunities. Nature Reviews Drug Discovery, 20(3), 200-216. https://doi.org/10.1038/s41573-020-00114-z
Balázs, V., Horváth, B., Kerekes, E., Ács, K., Kocsis, B., Varga, A., Böszörményi, A., Nagy, D., Krisch, J., Széchenyi, A., & Horváth, G. (2019). Anti-Haemophilus activity of selected essential oils detected by TLC-direct bioautography and biofilm inhibition. Molecules, 1-15. https://doi.org/10.3390/molecules24183301
Barcia, G. (2022). Fungal infections of cutaneous and superficial affectation. Dominio de Las Ciencias, 8(3), 2085-2113. https://doi.org/10.23857/dc.v8i3
Bedoya, M., Lázaro, B., Bizarro, A., Gutti, Y., Poma, K., y Cisnero, B. (2023). Eucaliptol: Una vista de la medicina tradicional en el siglo XXI. Eucalyptol: A View of Traditional Medicine in XXI Century. https://orcid.org/0000-0003-
Bukvicki, D., Kumur, A., Gottardi, D., Tabanelli, G., Montanari, C., Malik, A., & Guerzoni, M. (2014). Eucalyptus essential oil as a natural food preservative: In vivo and in vitro antiyeast potential. BioMed Research International, 2014, 1-9. https://doi.org/10.1155/2014/969143
Burt, S. (2004). Essential oils: Their antibacterial properties and potential applications in foods - A review. International Journal of Food Microbiology, 94(3), 223-253. https://doi.org/10.1016/j.ijfoodmicro.2004.03.022
Cama, D., Villanueva, E., Sakoda, B., y Monzon, L. (2020). Extraction and chemical characterization of essential oil from eucalyptus obtained by microwave and ultrasound. Revista de Investigación Altoandina, 22, 1-11. https://doi.org/10.18271/ria.2020.661
Cuenca, K., Lima, M., Pacheco, E., Vélez, E., y Zarzuelo, A. (2024). Effectiveness of lemon verbena (Cymbopogon citratus) in oral candidiasis: A systematic review. Clinical, Cosmetic and Investigational Dentistry, 16, 295-305. https://doi.org/10.2147/ccide.s478181
Cuenca, K., Pacheco, E., Granda, Y., Vélez, E., y Zarzuelo, A. (2022). Phytotherapy: A solution to decrease antifungal resistance in the dental field. Biomolecules, 12(6), 1-16. https://doi.org/10.3390/biom12060789
Dadar, M., Tiwari, R., Karthik, K., Chakraborty, S., Shahali, Y., & Dhama, K. (2018). Candida albicans - Biology, molecular characterization, pathogenicity, and advances in diagnosis and control – An update. Microbial Pathogenesis, 117, 128-138. https://doi.org/10.1016/j.micpath.2018.02.028
Dagli, N., Dagli, R., Mahmoud, R., & Baroudi, K. (2015). Essential oils, their therapeutic properties, and implication in dentistry: A review. Journal of International Society of Preventive and Community Dentistry, 5(5), 335-340. https://doi.org/10.4103/2231-0762.165933
García, C., Sarrion, M., y Bagán, J. (2014). Current treatment of oral candidiasis: A literature review. Journal of Clinical and Experimental Dentistry, 6(5), 576-582. https://doi.org/10.4317/jced.51798
Gharibpour, F., Shirban, F., Bagherniya, M., Nosouhian, M., Sathyapalan, T., & Sahebkar, A. (2021). The effects of nutraceuticals and herbal medicine on Candida albicans in oral candidiasis: A comprehensive review. https://doi.org/10.1007/978-3-030-64872-5_16
Gómez, A., López, Y., y Aguirre, M. (2022). Microbioma oral: Variabilidad entre regiones y poblaciones. Revista de La Facultad de Medicina, 65(5), 8-19. https://doi.org/10.22201/fm.24484865e.2022.65.5.02
Höferl, M., Wanner, J., Tabanca, N., Ali, A., Gochev, V., Schmidt, E., Kaul, V., Singh, V., & Jirovetz, L. (2020). Biological activity of Matricaria chamomilla essential oils of various chemotypes. Planta Medica International Open, 7(3), 114-121. https://doi.org/10.1055/a-1186-2400
Ivanov, M., Ćirić, A., & Stojković, D. (2022). Emerging antifungal targets and strategies. International Journal of Molecular Sciences, 23(5), 1-26. https://doi.org/10.3390/ijms23052756
Ivanov, M., Kannan, A., Stojković, D., Glamočlija, J., Calhelha, R., Ferreira, I., Sanglard, D., & Soković, M. (2021). Camphor and eucalyptol—Anticandidal spectrum, antivirulence effect, efflux pumps interference and cytotoxicity. International Journal of Molecular Sciences, 22, 1-14. https://doi.org/10.3390/ijms22020483
Jarrin, M., Caicedo, M., Garrido, P., y Cepeda, H. (2022). Terapia fotodinámica antimicrobiana sobre Candida albicans en superficies acrílicas de prótesis dentales: Estudio in vitro. Revista Eugenio Espejo, 16(3), 72-82. https://doi.org/10.37135/ee.04.15.08
Mihyaoui, A., Esteves Da Silva, J., Charfi, S., Castillo, M., Lamarti, A., & Arnao, M. (2022). Chamomile (Matricaria chamomilla L.): A review of ethnomedicinal use, phytochemistry and pharmacological uses. Life, 12(4), 1-41. https://doi.org/10.3390/life12040479
Noshirvani, N., Fasihi, H., Hashemi, M., Fazilati, M., Salavati, H., & Coma, V. (2019). Antioxidant and antimicrobial properties of carbohydrate-based films enriched with cinnamon essential oil by Pickering emulsion method. Food Packaging and Shelf Life, 19, 147-154. https://doi.org/10.1016/j.fpsl.2018.12.007
Palabaş, S., & Koca, C. (2020). Ethnobotanical survey of medicinal plants traded in herbal markets of Kahramanmaraş. Plant Diversity, 42(6), 443-454. https://doi.org/10.1016/j.pld.2020.12.003
Pazmiño, K. (2022). Epidemiología y susceptibilidad antifúngica en América Latina: Revisión bibliográfica narrativa. Trabajo de titulación previo a la obtención de título de Bioquímica Clínica. Pontificia Universidad Católica del Ecuador.
Sharifzadeh, A., & Shokri, H. (2016). Antifungal activity of essential oils from Iranian plants against fluconazole-resistant and fluconazole-susceptible Candida albicans. Original Research Article, 6(2).
Singh, O., Khanam, Z., Misra, N., & Srivastava, M. (2011). Chamomile (Matricaria chamomilla L.): An overview. Pharmacognosy Reviews, 5(9), 82-95. https://doi.org/10.4103/0973-7847.79103
Tamura, M., Watanabe, K., Mikami, Y., Yazawa, K., & Nishimura, K. (2001). Molecular characterization of new clinical isolates of Candida albicans and C. dubliniensis in Japan: Analysis reveals a new genotype of C. albicans with group I intron. Journal of Clinical Microbiology, 39(12), 4309-4315. https://doi.org/10.1128/JCM.39.12.4309-4315.2001
Tang, X., Shao, Y. L., Tang, Y. J., & Zhou, W. W. (2018). Antifungal activity of essential oil compounds (geraniol and citral) and inhibitory mechanisms on grain pathogens (Aspergillus flavus and Aspergillus ochraceus). Molecules, 23(9), 1-18. https://doi.org/10.3390/molecules23092108
Tiwari, A., & Khasbage, S. (2024). Oral thrush: An entity with diagnostic dilemma. Cureus, 2, 1-8. https://doi.org/10.7759/cureus.54916
Visan, A., & Negut, I. (2024). Coatings based on essential oils for combating antibiotic resistance. Antibiotics, 13(7), 1-37. https://doi.org/10.3390/antibiotics13070625
Wall, G., y Lopez, J. (2020). Current antimycotics, new prospects, and future approaches to antifungal therapy. Antibiotics, 9(8), 1-10. https://doi.org/10.3390/antibiotics9080445
Publicado
2025-04-01
Cómo citar
Duy-Pino, D., Cuenca-León, K. de los Ángeles, Orellana-Bravo, P., & Lima-Illescas, M. (2025). Evaluación in vitro de la efectividad del aceite esencial de Chamaemelum nobile y Eucalyptus frente a Candida albicans ATCC. CIENCIAMATRIA, 11(1), 615-633. https://doi.org/10.35381/cm.v11i1.1575
Sección
De Investigación
Derechos de autor 2025 Diana Cecilia Duy-Pino, Katherine de los Ángeles Cuenca-León, Paola Patricia Orellana-Bravo, Miriam Verónica Lima-Illescas
Esta obra está bajo licencia internacional Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0.
CC BY-NC-SA : Esta licencia permite a los reutilizadores distribuir, remezclar, adaptar y construir sobre el material en cualquier medio o formato solo con fines no comerciales, y solo siempre y cuando se dé la atribución al creador. Si remezcla, adapta o construye sobre el material, debe licenciar el material modificado bajo términos idénticos.
OAI-PMH URL: https://cienciamatriarevista.org.ve/index.php/cm/oai
